PittsburghV1, Main, Exploration, bibRecord, 001345

Short-T2 Imaging for Quantifying Concentration of Sodium (23Na) of Bi-Exponential T2 Relaxation

Identifieur interne : 001345 ( Main/Exploration ); précédent : 001344; suivant : 001346

Short-T2 Imaging for Quantifying Concentration of Sodium (23Na) of Bi-Exponential T2 Relaxation

Auteurs : Yongxian Qian [États-Unis] ; Ashok Panigrahy [États-Unis] ; Charles M. Laymon [États-Unis] ; Vincent K. Lee [États-Unis] ; Jan Drappatz [États-Unis] ; Frank S. Lieberman [États-Unis] ; Fernando E. Boada [États-Unis] ; James M. Mountz [États-Unis]

Source :

Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine [ 0740-3194 ] ; 2014.

RBID : PMC:4312273

Abstract

Purpose

This work intends to demonstrate a new method for quantifying concentration of sodium (²³Na) of bi-exponential T₂ relaxation in patients on MRI scanners at 3.0 Tesla.

Theory

Two single-quantum (SQ) sodium images acquired at very-short and short echo times (TE=0.5 and 5.0ms) are subtracted to produce an image of the short-T₂ component of the bi-exponential (or bound) sodium. An integrated calibration on the SQ and short-T₂ images quantifies both total and bound sodium concentrations.

Methods

Numerical models were used to evaluate signal response of the proposed method to the short-T₂ components. MRI scans on agar phantoms and brain tumor patients were performed to assess accuracy and performance of the proposed method, in comparison with a conventional method of triple-quantum filtering.

Results

A good linear relation (R²=0.98) was attained between the short-T₂ image intensity and concentration of bound sodium. A reduced total scan time of 22min was achieved under the SAR restriction for human studies in quantifying both total and bound sodium concentrations.

Conclusion

The proposed method is feasible for quantifying bound sodium concentration in routine clinical settings at 3.0 Tesla.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312273

DOI: 10.1002/mrm.25393
PubMed: 25078966
PubMed Central: 4312273

Affiliations:

Le document en format XML

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 Relaxation</title>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">This work intends to demonstrate a new method for quantifying concentration of sodium (<sup>23</sup>
Na) of bi-exponential T<sub>2</sub>
 relaxation in patients on MRI scanners at 3.0 Tesla.</p>
</sec>
<sec id="S2"><title>Theory</title>
<p id="P2">Two single-quantum (SQ) sodium images acquired at very-short and short echo times (TE=0.5 and 5.0ms) are subtracted to produce an image of the short-T<sub>2</sub>
 component of the bi-exponential (or bound) sodium. An integrated calibration on the SQ and short-T<sub>2</sub>
 images quantifies both total and bound sodium concentrations.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">Numerical models were used to evaluate signal response of the proposed method to the short-T<sub>2</sub>
 components. MRI scans on agar phantoms and brain tumor patients were performed to assess accuracy and performance of the proposed method, in comparison with a conventional method of triple-quantum filtering.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">A good linear relation (R<sup>2</sup>
=0.98) was attained between the short-T<sub>2</sub>
 image intensity and concentration of bound sodium. A reduced total scan time of 22min was achieved under the SAR restriction for human studies in quantifying both total and bound sodium concentrations.</p>
</sec>
<sec id="S5"><title>Conclusion</title>
<p id="P5">The proposed method is feasible for quantifying bound sodium concentration in routine clinical settings at 3.0 Tesla.</p>
</sec>
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Short-T2 Imaging for Quantifying Concentration of Sodium (23Na) of Bi-Exponential T2 Relaxation

Short-T2 Imaging for Quantifying Concentration of Sodium (23Na) of Bi-Exponential T2 Relaxation

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